DeepDETAILS

DeepDETAILS reconstructs cell-type-specific regulatory signals from mixed tissue profiles across modalities—including PRO-cap and ChIP-seq—without requiring matched single-cell assays for each data type.

Compendium

Search ready-to-use deconvolved regulatory tracks across 39 human tissues by assay, tissue, donor, and cell type.

Deconvolve your samples

Review the required bulk tracks, peak regions, single-cell reference fragments, and cell annotations needed to run DeepDETAILS.

FAQ

Find practical guidance on interpreting deconvolved tracks, release versions, reference samples, and portal data.

Why it matters

  • Cross-modality deconvolution: uses widely available sc/snATAC-seq to resolve bulk nascent transcription and histone modification signals.
  • Base-pair precision: maps promoters, enhancers, TSSs, and pausing sites at high resolution.
  • Robust in practice: works across sequencing depths, complex mixtures, unmatched references, donor variation, and batch effects.
Browse maps

Human regulatory compendium

We used DeepDETAILS to build a public atlas of cell-type-specific regulatory maps.

From variants to disease mechanisms

The resource enables cell-resolved interpretation of regulatory elements, noncoding variants, and disease mechanisms.